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Abstract:

Inno4Vac is a collaborative initiative between the public and private sectors aimed at
overcoming scientific challenges in vaccine development. The project seeks to create
predictive biological and mathematical models to enhance vaccine performance and bio-
manufacturing processes. The rProt monomer, is an antigen that plays a crucial role in the
bacterium’s ability to evade the human immune system by binding to human factor H.
Together with GSK and EVI (European vaccine initiative), DTU aims at developing a kinetic
model for the fProt expression in an E. coli process based on small-scale bioreactor data. In
this poster, we will present the optimal density (OD) and the growth rate model against the
experimental data. Apart from that, we will also include different metabolic pathways in the
future work.