Recording date:

Duration:
00:28:38

Speaker:
Prof. Dr. Victor de Lorenzo, Systems Biology Department, Centro Nacional de Biotecnologia, CSIC, 3 Madrid-Cantoblanco 28049, Spain

Abstract:

The concept of the chassis as a defined, reusable biological frame where non-native components can be plugged in and out to create new functionalities lies at the boundary between frontline bioengineering and more traditional recombinant  NA  echnology. As synthetic biology leaves academic laboratories and starts penetrating industrial and environmental realms regulatory agencies demand clear definitions and descriptions of SynBio constituents, processes and products. In this  alk, the state of the ongoing discussion on what is a chassis will be addressed, a non-equivocal nomenclature for the jargon used will be discussed along with objective criteria for distinguishing SynBio agents from traditional GMOs. The use of  enomic barcodes as unique identifiers is strongly advocated—as well as a shift from the mindset of control to that of stewardship for dealing with risks associated to novel genetic constructs. Finally, the soil bacterium Pseudomonas putida will  e presented as an example of the roadmap that one environmental isolate may go through to become a bona fide SynBio chassis.